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Publications

Original Literature

(*denotes corresponding author)

  1. Netusil NR, Boyd E, van Giffen Z, La Merrill MA,and Rainsberger E.  Can open spaces be self-financing: results from Portland, Oregon. Choices, 2000, Second Quarter, 21-23.
  2. Gordon R, Hunter K, La Merrill M, Sørensen P, Threadgill D, and Pomp D. Genotype x diet interactions in mice predisposed to mammary cancer: II. tumors and metastasis. Mammalian Genome, 2008, 19: 179-189, PMID18288525.
  3. La Merrill M, Baston DS, Denison MS, Birnbaum LS, and Threadgill DW. Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat. American Journal of Physiology-Endocrinology and Metabolism, 2009, 296: E203-210, PMID18840765/PMCID:PMC2636987.
  4. La Merrill M, Kuruvilla BS, Birnbaum LS, Pomp D, and Threadgill DW. Dietary fat alters pubertal body composition and P450 induction following maternal TCDD exposure in DBA/2J mice. Environmental Health Perspectives, 2009, 117: 1414-1419, PMID19750107/PMCID:PMC2737019.
  5. La Merrill M*, Gordon R, Hunter K, Threadgill D, and Pomp D. Dietary fat alters pulmonary metastasis of mammary cancers through cancer autonomous and non-autonomous changes in gene expression. Clinical and Experimental Metastasis, 2010, 27: 107-116, PMID20151316.
  6. La Merrill M, Harper R, Birnbaum LS, Cardiff RD, and Threadgill DW. Maternal TCDD along with a diet high in fat increases mammary cancer incidence in mice. Environmental Health Perspectives, 2010, 118: 596-601 (Cover article and Science Selection), PMID20435547/PMCID:PMC2866672.
  7. Gordon R, La Merrill M, Hunter K, Threadgill D, and Pomp D. Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis. Clinical and Experimental Metastasis, 2010, 27: 279-293, PMID20354763/PMCID: PMC439766.
  8. La Merrill M*, Stein CR, Landrigan P, Engel SM, and Savitz DA. Prepregnancy body mass index, smoking during pregnancy, and infant birth weight. Annals of Epidemiology, 2011, 21: 413-420, PMID21421328/PMCID:PMC3090467.
  9. La Merrill M*, Torres-Sanchez L, Ruiz-Ramos R, López-Carrillo L, Cebrián Garcia M, and Chen J. The association between first trimester micronutrient intake, MTHFR genotypes, and global DNA methylation in pregnant women.  Journal of Maternal-Fetal and Neonatal Medicine,2012, 25: 133-137, PMID21443409/PMCID:PMC3279137.
  10. La Merrill M*, Cirillo PM, Terry MB, Krigbaum NY, Flom JD, and Cohn BA. Prenatal exposure to the pesticide DDT and hypertension diagnosed in women before age 50: a longitudinal birth cohort study. Environmental Health Perspectives, 2013, 121: 594-599, doi:10.1289/ehp.1205921, PMID 23591545/PMCID 3673196.
  11. La Merrill M*,Karey E, Moshier E, Lindtner C, La Frano MR, Newman JW, Buettner C. Perinatal exposure of mice to the pesticide DDT impairs energy expenditure and metabolism in adult female offspring. PLOS ONE, 2014, 9: e103337, PMCID: PMC4116186.
  12. La Merrill MA*, Cirillo PM, Krigbaum NY, and Cohn BA. The impact of prenatal parental tobacco smoking on risk of diabetes mellitus in middle-aged women. Journal of Developmental Origins of Health and Disease, 2015, Feb 10:1-8, PMID25665487.
  13. Cohn BA, La Merrill M, Krigbaum NY, Yeh G, Park JS, Zimmermann L, and Cirillo PM. DDT exposure in utero and breast cancer. Journal of Clinical Endocrinology and Metabolism, 2015, 8: 2865-2872, PMID 26079774.
  14. Ishikawa T, Graham JL, Stanhope KL, Havel PJ, La Merrill MA*. Effect of DDT exposure on lipids and energy balance in obese Sprague-Dawley rats before and after weight loss. Toxicology Reports, 2015, 2: 990-995, PMID processing. Open Access.
  15. La Merrill MA*, Sethi, S, Benard L, Moshier E, Haraldsson B, Buettner C. Perinatal DDT exposure induces hypertension and cardiac hypertrophy in adult mice. Environmental Health Perspectives, 2016,124:1722-1727, doi:10.1289/EHP164, PMID 27325568.
  16. Green AJ, Graham JL, Gonzalez EA, La Frano MR, Petropoulou S-SE, Park J-S, Newman JW, Stanhope KL, Havel PJ, La Merrill MA*. Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-Type 2 Diabetes Mellitus rats. Invited special issue of Reproductive Toxicology “Developmental Basis of Health and Disease”, 2017, 68: 119-129, doi:10.1016/j.reprotox.2016.07.009, PMID 27421578.
  17. Cano-Sancho G, Smith A, La Merrill MA*. Triphenyl phosphate enhances adipogenic differentiation, glucose uptake and lipolysis via endocrine and noradrenergic mechanisms. In Vitro Toxicology, 2017, 40: 280-288, PMID 28163246.
  18. Smith AM, Smith AT, La Merrill MA, Liaw J, Steinmaus C. 2,4-Dichlorophenoxyacetic Acid (2,4-D) and Risk of Non-Hodgkin Lymphoma: A meta-analysis accounting for exposure levels. Annals of Epidemiology, 2017, 27: 281-289.
  19. Cano-Sancho G, Salmon AG, La Merrill MA*. Association between exposure to p,p'-DDT and its metabolite p,p'-DDE with obesity: integrated systematic review and meta-analysis. Environmental Health Perspectives, 2017, doi:10.1289/EHP527. Featured as an EHP Science Selection: doi:10.1289/EHP2545.
  20. La Merrill MA*, Lind PM, Salihovic S, van Bavel B, Lind L. The association between p,p’-DDE levels and left ventricular hypertrophy is mainly mediated by obesity. Environmental Research, 2018, doi:10.1016/j.envres.2017.10.031.
  21. Daniels SI, Chambers JC, Sanchez SS, La Merrill MA, Hubbard AE, Macherone A, McMullin M, Zhang L, Elliot P, Smith MT, Kooner J. Elevated levels of organochlorine pesticides in South Asian Immigrants are associated with an increased risk of diabetes. Journal of the Endocrine Society, 2018, doi:10.1210/js.2017-00480.
  22. Eiserich JP, Ott SP, Kadir T, Morrissey BM, Hayakawa KA, La Merrill MA, Cross CE. Quantitative assessment of cyanide in cystic fibrosis sputum and its oxidative catabolism by hypochlorous acid. Free Radical Biology and Medicine, 2018,129:146-154. doi: 10.1016/j.freeradbiomed.2018.09.007, PMID 30213640.
  23. Cohn BA, Cirillo PM, La Merrill MA*. Correlation of body mass index with serum DDTs predicts lower risk of breast cancer before the age of 50: prospective evidence in the Child Health and Development Studies. Journal of Exposure Science & Environmental Epidemiology, 2018, doi:10.1038/s41370-018-0072-7, PMID 30224754.
  24. da Costa CS, Miranda-Alves L, La Merrill MA, Silva IV, Graceli JB.  The tributyltin leads to obesogenic mammary gland abnormalities in adult female rats. Toxicology Letters, 2019, 307: 59-71, doi:10.1016/j.toxlet.2019.02.016.
  25. Hu X, Li S, Cirrilo P, Krigbaum N, Tran V, Ishikawa T, La Merrill MA, Jones DP, Cohn B. Metabolome Wide Association Study of serum DDT and DDE in Pregnancy and Early Postpartum, Reproductive Toxicology, 2019, doi:10.1016/j.reprotox.2019.05.059.
  26. Azhagiya Singam ER, Tachachartvanich P, La Merrill MA, Smith MT, Durkin KA. Structural Dynamics of Agonist and Antagonist Binding to the Androgen Receptor, Journal of Physical Chemistry B, 2019, 123, 7657-7666, doi:/10.1021/acs.jpcb.9b05654.
  27. La Merrill MA*, Johnson CL, Smith MT, Kandula NR, Macherone A, Pennell KD, Kanaya AM. Exposure to persistent organic pollutants (POPs) and their relationship to hepatic fat and insulin insensitivity among Asian Indian immigrants in the United States. Environmental Science and Technology, 2019, 53,13906-13918, doi:10.1021/acs.est.9b03373.
  28. Cohn BA, La Merrill MA, Krigbaum NY, Wang M, Park JS, Petreas M, Yeh G, Hovey RC, Zimmermann L, PM Cirillo. In utero exposure to poly- and perfluoroalkyl substances (PFASs) and subsequent breast cancer, Reproductive Toxicology, 2020, 92: 112-19, doi: 10.1016/j.reprotox.2019.06.012.
  29. Azhagiya Singam ER, Tachachartvanich P, Fourches D, Soshilov A, Hsieh JCY, La Merrill MA, Smith MT, Durkin KA. Structure-Based Virtual Screening of Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) as Endocrine Disruptors of Androgen Receptor Activity Using Molecular Docking and Machine Learning. Environmental Research, 2020.
  30. Tachachartvanich P, Azhagiya Singam,ER, Durkin KA, Smith MT, La Merrill MA*. Structure-based discovery of the endocrine disrupting effects of hydraulic fracturing chemicals as novel androgen receptor antagonists. Chemosphere, 2020, 257,127178,doi: 10.1016/j.chemosphere.2020.127178.
  31. La Merrill MA*, Krigbaum NY, Cirillo PM, Cohn BA. Association between maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) and risk of obesity. International Journal of Obesity, 2020, doi: 10.1038/s41366-020-0586-7, PMID 32415255.
  32. Castriota F, Zushin PJ, Sanchez SS, Phillips RV, Hubbard A, Stahl A, Smith MT, Wang JC, La Merrill MA*. Chronic arsenic exposure impairs adaptive thermogenesis in male C57BL/6J mice. American Journal of Physiology-Endocrinology and Metabolism, 2020, E667-E677, doi:10.1152/ajpendo.00282.2019. 
  33. Valvi D, Walker D, Inge T, Bartell S, Jenkins T, Helmrath M, Ziegler T, La Merrill MA, Eckel S, Conti D, Liang Y, McConnell R, Chatzi L. Environmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: a pilot untargeted metabolomic approach. Environmental International, 2020, 143:105957, doi: 10.1016/j.envint.2020.105957, PMID 32683211. 
  34. Elmore SE, Cano-Sancho G, La Merrill MA*. Disruption of normal adipocyte development and function by methyl- and propyl- paraben exposure. Toxicology Letters, 2020, 334: 27, doi: 10.1016/j.toxlet.2020.09.009, PMID 32956827.
  35. Jugan J, Lind PM, Salihovic S, Stubleski J, Kärrman A, Lind L, La Merrill MA*. The associations between p,p’-DDE levels and plasma levels of lipoproteins and their subclasses in an elderly population determined by analysis of lipoprotein content. Lipids in Health and Disease, 2020, 19:249, doi: 10.1186/s12944-020-01417-1, PMID 33287856.
  36. Vogel CFA, Lazennec G, Kado SY, Dahlem C, He Y, Castaneda A, Ishihara Y, Vogeley C, Rossi A, Haarmann-Stemmann T, Jugan JA, Mori H, Borowsky AD, La Merrill MA, Sweeney C. Targeting the aryl hydrocarbon receptor signaling pathway in breast cancer development. Frontiers in Immunology, 2021, doi: 10.3389/fimmu.2021.625346, PMID 33763068.
  37. Cirillo P, La Merrill MA (co-first authors), Krigbaum N, Cohn B. Grandmaternal perinatal serum DDT in relation to granddaughter early menarche and adult obesity: three generations in the Child Health and Development Studies cohort. Cancer Epidemiology, Biomarkers & Prevention, 2021, 30:1480, doi: 10.1158/1055-9965.EPI-20-1456, PMID 33853850.
  38. vonderEmbse AN, Elmore SE, Jackson KB, Habecker BA, Manz KE, Pennell KE, Lein PJ, La Merrill MA*. Developmental exposure to DDT or DDE alters sympathetic innervation of brown adipose in adult female mice. Environmental Health, 2021, 20: 37, doi: 10.1186/s12940-021-00721-2, PMID 33794904.
  39. Manz KE, Yamada K, Scheidl L, La Merrill MA, Lind L, Pennell KD. Targeted and non-targeted detection and characterization of trace organic chemicals in organic chemicals in human serum and plasma using QuEChERS. Toxicological Sciences, 2021, 185:77-88, doi: 10.1093/toxsci/kfab121, PMID 34668567.
  40. Stratakis N, Rock S, La Merrill MA, Saez M, Robinson O, Fecht D, Vrijheid M, Valvi D, Conti DV, McConnell R, Chatzi VL. Prenatal exposure to persistent organic pollutants and childhood obesity: a systematic review and meta-analysis of human studies. Obesity Reviews, 2022, 23:e13383, doi: 10.1111/obr.13383, PMID: 34766696.
  41. Tachachartvanich P, Ramaprasad ASE, Durkin KA, Furlow JD, Smith MT, La Merrill MA*. In Vitro Characterization of the Endocrine Disrupting Effects of Per- and Poly-fluoroalkyl Substances (PFASs) on the Human Androgen Receptor. Journal of Hazardous Materials, 2022, 429: 128243, doi: 10.1016/j.jhazmat.2022.128243. 
  42. Azhagiya Singam ER, Smith MT, McCoy D, Hubbard AE, La Merrill MA, Durkin KA. Predicting the binding of small molecules to nuclear receptors using machine learning. Briefings in Bioinformatics, 2022, 23:bbac114, doi: 10.1093/bib/bbac114, PMID 35383362.
  43. Costello E, Rock S, Stratakis N, Eckel SP, Walker DI, Valvi D, Cserbik D, Jenkins T, Xanthakos SA, Kohli R, Sisley S, Vasiliou V, La Merrill MA, Rosen H, Conti DV, McConnell R, Chatzi VL. Exposure to per- and polyfluoroalkyl substances and markers of liver injury: a systematic review and meta-analysis. Environmental Health Perspectives, 2022, 130: 46001, doi: 10.1289/EHP10092, PMID: 35475652.
  44. Azhagiya Singam ER, Durkin KA, La Merrill MA, Furlow JD, Wang JC, Smith MT. The vitamin D receptor as a potential target for the toxic effects of per- and polyfluoroalkyl substances (PFASs): an in-silico study, Environmental Research, 2022, 217: 114832, doi: 10.1016/j.envres.2022.114832, PMID 3643651.
  45. Mouat JS, Li X, Neier K, Zhu Y, Mordaunt CE, La Merrill MA, Lehmler HJ, Jones MP, Lein PJ, Schmidt RJ, LaSalle JM. Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment. Environmental Research, 2023, 220: 115227, doi: 10.1016/j.envres.2023.115227, PMID 36608759.
  46. Tong JH, Elmore S, Huang SS, Tachachartvanich P, Manz K, Pennell K, Wilson MD, Borowsky A, La Merrill MA. Chronic exposure to low levels of parabens increases mammary cancer growth and metastasis in mice. Endocrinology, 2023, in press.

Review Articles and Scientific Statements

  1. La Merrill MA, Parent KE, and Kirchhoff MM.  Green Chemistry: stopping pollution before it starts. ChemMatters, 2003, April, 7-10.
  2. La Merrill MA, Parent KE, and Kirchhoff MM.  Greener Chemistry in Every Career. In Chemistry, 2003, 12, 15-19.
  3. La Merrill MA and Parent KE. Packaging food with green chemistry. In Chemistry, 2003, 13, 20-21.
  4. La Merrill M* and Birnbaum LS.Childhood obesity and environmental chemicals. Invited by Mount Sinai Journal of Medicine, 2011, 78: 22-48, PMID:21259261/ PMCID:PMC3076189.
  5. La Merrill M, Emond C, Kim MJ, Antignac JP, Le Bizec B, Clement K, Birnbaum LS, and Barouki R. Toxicological function of adipose tissue: focus on persistent organic pollutants. Environmental Health Perspectives, 2013, 121: 413-420 (Science Selection), PMID:23221922/PMCID:PMC3569688.
  6. Gore A, Crews D, Doan LL, La Merrill M, Patisaul H and Zota A. Introduction to Endocrine Disrupting Chemicals: a guide for public interest organizations and policy-makers. Endocrine Society and IPEN, 2014, http://press.endocrine.org/edc.
  7. Heindel J, Vom Saal FS, Blumberg B, Bovolin P, Calamandrei G, Ceresini G, Cohn BA, Fabbri E, Gioiosa L, Kassotis C, Legler J, La Merrill M, Rizzir L, Machtinger R, Mantovani A, Mendez MA, Montanini L, Molteni L, Nagel SC, Parmigiani S, Panzica G, Paterlini S, Pomatto V,Ruzzin J, Sartor G, Schug TT, Street ME, Suvorov A, Volpi R, Zoeller RT, Palanza P. Parma consensus statement on metabolic disruptors. Environmental Health, 2015, 14: 54-61, PMID: 26092037/PMCID:PMC4473834.
  8. Loomis D, Guyton K, Grosse Y, El Chissasi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Mattock H, Straif K, Intenational Agency for Research on Cancer Monograph Working Group (Kogevinas M, Larramendy ML, Stewart BW, Sanderson T, Guenel P, Cocco P, Fukushima S, Cebrian ME, Lopez Carrillo LT, Vermeulen R, Naidoo S, Prapamontol T, Martin FL, Rushton L, Alavanja M, Bosland M, Chhabra RS, Chiu W, De Roos A, Herbert R, La Merrill M, Reif DM, Roy D, Smith MT, Thomas K, Wolff M.) Carcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid. The Lancet Oncology, 2015, S1470:81-9, doi: 10.1016/S1470-2045(15)00081-9, PMID 26111929.
  9. La Merrill MA*. The economic legacy of endocrine-disrupting chemicals. Invited by Lancet Diabetes and Endocrinology, 2016, 4: 961-962, doi:10.1016/S2213-8587(16)30279-0, PMID27765540.
  10. Gill JA, La Merrill MA*. An emerging role for epigenetic regulation of Pgc-1a expression in environmentally stimulated brown adipose thermogenesis, Environmental Epigenetics, 2017, 3:dvx009, doi:10.1093/eep/dvx009.
  11. Mendrick DL, Diehl AM, Topor LS, Dietert RR, Will Y, La Merrill MA, Bouret S, Varma V, Hastings KL, Schug TT, Emeigh Hart SG, Burleson FG. Metabolic syndrome and associated diseases: from the bench to the clinic, Toxicological Sciences, 2018, 162: 36-42, doi:10.1093/toxsci/kfx233.
  12. Elmore SE, La Merrill MA*. Oxidative phosphorylation impairment by DDT and DDE, Frontiers in Endocrinology, 2019, 10:1-8, doi:10.3389/fendo.2019.00122.
  13. La Merrill MA. The environmental chemicals that change our minds and bodies. The Lancet Diabetes & Endocrinology, 2019, 8: 16, doi: 10.1016/S2213-8587(19)30177-9.
  14. La Merrill MA*, Vandenberg LN, Smith MT, Goodson W, Browne P, Patisaul HB, Guyton KZ, Kortenkamp A, Cogliano VJ, Woodruff TJ, Rieswijk L, Sone H, Korach KS, Gore AC, Zeise L, Zoeller TR. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. Nature Reviews Endocrinology, 2019, doi:10.1038/s41574-019-0273-8.
  15. Castriota F, Rieswijk L, Dahlberg S, La Merrill MA, Steinmaus C, Smith MT, Wang JC. A state-of-the-science review of arsenic’s effects on glucose homeostasis in experimental models. Environmental Health Perspective, 2020, 128,16001,doi:10.1289/EHP4517, PMID31898917.
  16. Smith M, Guyton KZ, Kleinstreuer N, Borrel A, Cardenas A, Chiu W, Felsher DW, Gibbons C, Goodson W, Houck K, La Merrill MA, Lebrec H, Lowe L, McHale C, Minocherhomji S, Rieswijk L, Sandy M, Hideko S, Wang A, Zhang L, Zeise L, Fielden M. The key characteristics of carcinogens: relationship to the hallmarks of cancer, relevant biomarkers, and assays to measure them. Cancer Epidemiology and Prevention Biomarkers, 2020, doi:10.1158/1055-9965.EPI-19-1346, PMID32152214.
  17. Rider CV, McHale CM, Webster TF, Lowe L, Goodson WH, La Merrill MA, Rice G, Zeise L, Zhang L, Smith MT. Using the key characteristics of carcinogens to develop research on chemical mixtures and cancer. Environmental Health Perspectives, 2021, doi:10.1289/EHP8525, PMID33784186.

Invited Book Chapters

  1. Landrigan P, Morland K, and La Merrill M. Chapter 104: Environment and heart disease in Hurst’s The Heart, 13th edition, 2011; McGraw-Hill, Columbus, OH.
  2. La Merrill M*, Taylor K, Thayer KA, and Birnbaum LS. Chapter 36: The environment during development, obesity, and diabetes in The Oxford Textbook of Environmental Pediatrics: Environmental Influences on Health, Development and Disease, 1st edition, 2013; Oxford University Press, Oxford, England.
  3. Barouki R, Antignac JP, Emond C, Clement K, Birnbaum L, La Merrill M, Kim MJ. Adipose tissue pollutants and obesity in The ECOG's eBook on Child and Adolescent Obesity (free), 1st edition, 2015; European Childhood Obesity Group, Brussels, Belgium.
  4. La Merrill M, Galvez M. Chapter 29: Endocrine disrupting chemicals in Pediatric Environmental Health, 4th edition, 2019; American Academy of Pediatrics, Itasca, IL.

 

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